Since it is the gang Catalina is leading, they are hostile to the player since the beginning of the game (even though their territory is not reachable by normal means before the mission Last Requests is completed).

Their main enemies are the Leone Family and the Yakuza. They heavily involved in the drugs trade and are known to deal with the Uptown Yardies. First arriving in 1998, they quickly gained control of parts of Staunton Island and Shoreside Vale. The Colombian Cartel or simply the Cartel is a Colombian drug cartel co-led by Catalina and Miguel. They become hostile towards Claude after he commits a massacre of Diablo members under orders of Yardies leader King Courtney. They are arch rivals of the Uptown Yardies. Three years later, the gang still has limited fire power, however, and they continue to hold onto Hepburn Heights.

They arrived in 1998 but, due to their limited fire power, could only gain control of one district. The Diablos is a Puerto Rican street gang led by El Burro and based in Hepburn Heights, Portland Island. They become hostile to the player after the missions Trial By Fire or The Pick-Up. They control the Chinatown and the Callahan Point areas of Portland and are the enemies of the Leone Family. The Triads are a Chinese criminal organization that arrived in the city in 1998, with help from the Sicilian Mafia. They become hostile towards Claude after he kills their leader Salvatore Leone under orders of Yakuza leader Asuka Kasen in the mission Sayonara Salvatore. They have a fierce rivalry with the Triads. They had previously controlled more of the city, but since 1999 they saw their influence greatly reduced. They are based in Portland Island, in particular Saint Mark's, but also have interests in the Red Light District, Chinatown and Trenton. Led by Salvatore Leone, the Leone Family is an Italian mafia that has been a force in Liberty City longer than any other gang.

2.1 Forelli Family (aka the Forelli Bros.).

Colombian gang car in gta 3